Deficiency of spermatogenesis and reduced expression of spermatogenesis-related genes in prefoldin 5-mutant mice
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چکیده
منابع مشابه
Deficiency of spermatogenesis and reduced expression of spermatogenesis-related genes in prefoldin 5-mutant mice
MM-1α is a c-Myc-binding protein and acts as a transcriptional co-repressor in the nucleus. MM-1α is also PDF5, a subunit of prefoldin that is chaperon comprised of six subunits and prevents misfolding of newly synthesized nascent polypeptides. Prefoldin also plays a role in quality control against protein aggregation. It has been reported that mice harboring the missense mutation L110R of MM-1...
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Spermatogenesis is a complex and well-orchestrated process, in which Spermatogonial Stem Cells (SSCs) divide and differentiate to produce unlimited numbers of mature spermatozoa. This process is continuous throughout the adult life in most mammals. The seminiferous epithelium consists of only one somatic cell type, sertoli cell [1] and many different germ cell types [2]. Sertoli cells play a nu...
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An experimental ischemia (EI)-induced mouse model was used to analyze pathological and biochemical alterations in testes. Initial morphological changes were observed in Sertoli cells of EI testes at the light microscopic level. Examination of the ultrastructure using transmission electron microscopy confirmed that Sertoli cells were partially detached from the basement membrane of the seminifer...
متن کاملHemicastration induced spermatogenesis-related DNA methylation and gene expression changes in mice testis
OBJECTIVE Hemicastration is a unilateral orchiectomy to remove an injured testis, which can induce hormonal changes and compensatory hypertrophy of the remaining testis, and may influence spermatogenesis. However, the underlying molecular mechanisms are poorly understood. Here, we investigated the impact of hemicastration on remaining testicular function. METHODS Prepubertal mice (age 24 days...
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ژورنال
عنوان ژورنال: Biochemistry and Biophysics Reports
سال: 2015
ISSN: 2405-5808
DOI: 10.1016/j.bbrep.2015.03.005